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Some retrospective data shows patients on antidepressants lose slightly less weight overall on GLP-1 agonists, but this likely reflects the underlying depression rather than a pharmacological conflict

In reality, consistent use, proper dosage, and lifestyle adjustments are essential for the best results

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Another 68-week trial with over 3000 obese or overweight adults found 17.4% body weight loss with semaglutide versus only 2.9% with placebo plus diet/exercise counseling